06/20/2020

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As Mercadante The stimulation of the receivers 5-HT diminishes the set free amount. Soon, such receivers have regulatory action on the release of the neurotransmitter, limiting it when the amine concentrations in the sinptica crack reach high levels. Thus, therefore, a well known mechanism of negative feedback (negative feedback). The efficient medicines for the treatment of the fisiopatologia of the TOC are related to the serotonrgica neurotransmisso. It perceived, originally this treatment due to use of antidepressants that increases function serotonrgica (IRS) - they are selective (fluoxina, fluvoxina, paroxitinia, pertrolina, they citolopram) that they are called (ISRS) or as the clomipramina that started to be the pado of comparison of studies of effectiveness of other frmacos in the TOC (pado-gold), improve the obsessive-compulsory symptoms, entretando the ones that acts, preferential on the noradrenalina (nortripilina, desipremina) are little or nothing efficient (GRAEFF, F.G., 2001). Medication for at least three months a maximum dose for the evaluation of its effectiveness must be kept. In case that the symptoms are controlled, its suspension can be started the reduction for a dosage of maintenance six months and after be tried after eighteen months. For the dosage experiments (THOREN et al, 1980); (Duck et al, 1988) and Leonard et al, 1991) with its experimental works had proven that with the intervention of the dosage the fallen again one is rule to (SOCs), except for some medicines that possess bigger stocking-life, according to...

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